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Autotuning technology is a keystone of ttgLabs flagman product, TTG Apptimizer toolkit, that is available in CUDA edition for MS Windows and Linux used with GPUs from NVIDIA and in OpenCL version for GPUs from Intel and AMD. TTG Apptimizer accomplishes several dynamic optimization procedures thus enabling to use all available processing units of hybrid HPC system simultaneously and providing load balancing between them. TTG Apptimizer enables developers to optimize resource-demanding applications for GPU-based systems and, with minimal recoding and time spending, to easily achieve an efficient usage of all processing units, dynamic load balancing, selection of the optimal computational kernels, and detection of the required level of parallelism. Key advantages of this platform-neutral solution are its ability to tailor automatically an application to the hardware and data structure, to increase significantly the application performance and to shorten dramatically the time-to-market.